Biomedical Research · Heidelberg
Peptide science, from sequence to study.
Novera designs, synthesises and characterises bioactive peptides for preclinical research in metabolism, infection, oncology and tissue repair.
Im Neuenheimer Feld 340 · Heidelberg · DE
The native incretin hormone. Swapping Ala8 for Aib, Lys34 for Arg and attaching a C18 fatty diacid to Lys26 turns it into semaglutide, extending its half-life from about 2 minutes to about one week.
What peptides are
Short chains with precise jobs
A peptide is a chain of amino acids joined by amide (peptide) bonds. By convention, chains of roughly 2 to 50 residues are peptides; longer, folded chains are proteins.
In the body, peptides act as hormones, neurotransmitters, growth factors and antimicrobial defences. They bind their targets with high selectivity, which gives them fewer off-target effects than many small molecules.
Their weakness is stability: proteases cleave them within minutes and the kidneys clear them fast. Much of modern peptide research is about engineering around that, with cyclisation, non-natural amino acids, lipidation and PEGylation.
Size in context · amino acids
3915313751585Bar length is proportional to residue count. Albumin, a typical plasma protein, is shown for comparison.
Peptide library
Reference peptides we study
Sequences in one-letter code. Molecular weights are average masses in daltons. Filter by field or search by name or sequence.
| Peptide | Sequence | Residues | MW (Da) | Field | Status |
|---|
Lower-case letters mark D-amino acids. Aib = α-aminoisobutyric acid. K* = lipidated lysine. Status refers to regulatory approval in the EU and/or US; "investigational" compounds are not approved for human use.
Research areas
Where peptides are changing medicine
Methods
From design to data in six steps
Every peptide that leaves our bench passes the same documented workflow.
Quality control
Identity, purity and content, documented
PurityReverse-phase HPLC at 214 nm. Research grade ≥ 95 %, cell-based work ≥ 98 %.
IdentityESI or MALDI-TOF mass spectrometry; observed mass within ±1 Da of theoretical.
Net peptide contentAmino-acid analysis or nitrogen content, so concentrations reflect peptide, not counter-ions and water.
EndotoxinLimulus assay on request for in vivo and immune-cell studies.
- Product
- Oxytocin
- Sequence
- CYIQNPLG-NH₂
- Theoretical mass
- 1007.2 Da
- Observed mass (ESI-MS)
- 1007.4 Da
- PASS
- HPLC purity (214 nm)
- 98.6 %
- PASS
- Net peptide content
- 84.1 %
- PASS
- Appearance
- White lyophilised powder
- PASS
- Storage
- −20 °C
Illustrative values showing the format of our certificates. For research use only.
Research notes
Background reading from the lab
Contact
Work with Novera
We collaborate with universities, clinics and biotech companies on custom peptide synthesis, analytical services and joint research projects. Tell us about your sequence, quantity and application, and we will reply within two working days.
69580 Heidelberg, Germany